WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SKIC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKIC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKIC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,077,036–78,077,991 | 222.0 kb | Distal (>10kb) Multiome | 552 | |
| chr15:78,130,851–78,132,005 | 168.1 kb | Distal (>10kb) Multiome | 769 | |
| chr15:78,148,893–78,150,142 | 150.3 kb | Distal (>10kb) Multiome | 746 | |
| chr15:78,264,436–78,265,112 | 34.9 kb | Distal (>10kb) Multiome | 241 | |
| chr15:78,299,130–78,299,874 | 52 bp | At TSS Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 4.3 kb | Proximal (<10kb) Multiome | 287 | |
| chr15:78,308,484–78,308,723 | 8.9 kb | Proximal (<10kb) | 246 | |
| chr15:78,340,100–78,340,745 | 40.7 kb | Distal (>10kb) Multiome | 194 | |
| chr15:78,348,106–78,348,824 | 48.9 kb | Distal (>10kb) Multiome | 178 | |
| chr15:78,437,554–78,438,897 | 138.6 kb | Distal (>10kb) Multiome | 918 | |
| chr15:78,506,965–78,508,087 | 207.9 kb | Distal (>10kb) Multiome | 674 | |
| chr15:78,539,941–78,541,020 | 240.9 kb | Distal (>10kb) Multiome | 773 | |
| chr15:78,564,790–78,566,388 | 265.9 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the SKIC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.