Predicted to be involved in regulation of gene expression. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SIX3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIX3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIX3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:44,932,798–44,933,373 | 8.1 kb | Proximal (<10kb) | 62 | |
| chr2:44,934,122–44,936,090 | 5.4 kb | Proximal (<10kb) | 246 | |
| chr2:44,937,044–44,939,675 | 1.8 kb | Proximal (<10kb) | 512 | |
| chr2:44,939,777–44,940,009 | 1.5 kb | Proximal (<10kb) | 43 | |
| chr2:44,940,953–44,942,676 | at TSS | At TSS | 260 | |
| chr2:44,943,778–44,944,903 | 2.3 kb | Proximal (<10kb) | 119 | |
| chr2:44,945,722–44,946,385 | 4.2 kb | Proximal (<10kb) | 150 | |
| chr2:44,949,379–44,950,322 | 7.9 kb | Proximal (<10kb) | 186 |
Genomic view of the SIX3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.