This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Transcription factors with Perturb-seq knockdown data for SIVA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIVA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIVA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,563,886–104,564,429 | 189.0 kb | Distal (>10kb) Multiome | 258 | |
| chr14:104,604,320–104,605,057 | 148.3 kb | Distal (>10kb) Multiome | 410 | |
| chr14:104,644,552–104,645,399 | 108.2 kb | Distal (>10kb) Multiome | 73 | |
| chr14:104,650,132–104,650,778 | 102.7 kb | Distal (>10kb) Multiome | 479 | |
| chr14:104,677,345–104,678,671 | 75.1 kb | Distal (>10kb) Multiome | 661 | |
| chr14:104,681,399–104,683,204 | 71.0 kb | Distal (>10kb) Multiome | 586 | |
| chr14:104,689,023–104,690,058 | 63.6 kb | Distal (>10kb) Multiome | 571 | |
| chr14:104,708,563–104,709,104 | 44.4 kb | Distal (>10kb) Multiome | 300 | |
| chr14:104,723,348–104,724,675 | 29.1 kb | Distal (>10kb) Multiome | 710 | |
| chr14:104,752,085–104,753,760 | 229 bp | At TSS Multiome | 924 | |
| chr14:104,768,378–104,769,330 | 15.7 kb | Distal (>10kb) Multiome | 614 | |
| chr14:104,793,970–104,794,513 | 41.1 kb | Distal (>10kb) Multiome | 302 | |
| chr14:104,795,078–104,796,304 | 42.6 kb | Distal (>10kb) Multiome | 456 | |
| chr14:104,799,612–104,801,541 | 46.5 kb | Distal (>10kb) Multiome | 749 | |
| chr14:104,815,517–104,816,820 | 62.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr14:104,825,631–104,828,095 | 74.7 kb | Distal (>10kb) Multiome | 653 | |
| chr14:104,863,847–104,866,207 | 111.1 kb | Distal (>10kb) Multiome | 743 | |
| chr14:104,932,604–104,933,678 | 180.3 kb | Distal (>10kb) Multiome | 498 | |
| chr14:104,967,607–104,968,024 | 214.8 kb | Distal (>10kb) Multiome | 196 | |
| chr14:104,975,803–104,976,561 | 223.0 kb | Distal (>10kb) Multiome | 394 | |
| chr14:104,977,531–104,979,147 | 225.3 kb | Distal (>10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 232.6 kb | Distal (>10kb) Multiome | 518 | |
| chr14:105,020,271–105,022,072 | 268.1 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 292.7 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the SIVA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.