This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SIRT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIRT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIRT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,328,084–13,329,043 | 246.0 kb | Distal (>10kb) Multiome HiCAR | 848 | |
| chr6:13,422,574–13,423,098 | 151.7 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr6:13,485,963–13,488,715 | 86.8 kb | Distal (>10kb) Multiome | 753 | |
| chr6:13,532,018–13,532,632 | 42.3 kb | Distal (>10kb) Multiome | 66 | |
| chr6:13,573,806–13,575,472 | 67 bp | At TSS Multiome | 1136 | |
| chr6:13,614,519–13,616,157 | 40.8 kb | Distal (>10kb) Multiome | 1137 | |
| chr6:13,710,505–13,712,451 | 137.5 kb | Distal (>10kb) Multiome | 996 | |
| chr6:13,813,584–13,814,884 | 239.9 kb | Distal (>10kb) Multiome | 1028 | |
| chr6:13,859,849–13,861,074 | 285.9 kb | Distal (>10kb) Multiome | 81 | |
| chr6:13,873,408–13,874,382 | 299.4 kb | Distal (>10kb) Multiome | 915 |
Genomic view of the SIRT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.