This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SIRT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIRT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIRT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,394,369–38,395,035 | 505.0 kb | Distal (>10kb) Multiome HiCAR | 191 | |
| chr19:38,402,504–38,403,738 | 496.6 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr19:38,417,766–38,418,568 | 481.6 kb | Distal (>10kb) Multiome HiCAR | 407 | |
| chr19:38,506,710–38,507,745 | 392.5 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr19:38,514,956–38,515,568 | 384.4 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr19:38,595,857–38,597,322 | 303.3 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr19:38,617,752–38,619,569 | 280.7 kb | Distal (>10kb) Multiome | 835 | |
| chr19:38,647,137–38,648,653 | 252.2 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 233.4 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 216.0 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 164.4 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 162.7 kb | Distal (>10kb) Multiome HiCAR | 493 | |
| chr19:38,754,913–38,755,455 | 144.5 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 67.8 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 47.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 29.7 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 145 bp | At TSS Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 31.0 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 50.2 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 77.0 kb | Distal (>10kb) Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 96.5 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 131.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:39,125,485–39,126,290 | 226.1 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the SIRT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.