SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:100,455,112–100,456,608 | 8.3 kb | Proximal (<10kb) | 214 | |
| chr6:100,456,716–100,456,855 | 8.1 kb | Proximal (<10kb) | 31 | |
| chr6:100,457,260–100,459,013 | 5.9 kb | Proximal (<10kb) | 207 | |
| chr6:100,460,652–100,461,691 | 3.2 kb | Proximal (<10kb) | 270 | |
| chr6:100,463,768–100,465,658 | at TSS | At TSS | 354 | |
| chr6:100,466,394–100,467,864 | 1.5 kb | Proximal (<10kb) | 229 | |
| chr6:100,469,271–100,469,938 | 4.3 kb | Proximal (<10kb) | 114 |
Genomic view of the SIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.