This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for SHOC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHOC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHOC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:110,643,641–110,644,831 | 275.3 kb | Distal (>10kb) Multiome | 427 | |
| chr10:110,671,928–110,672,573 | 247.3 kb | Distal (>10kb) Multiome | 567 | |
| chr10:110,701,236–110,702,762 | 217.7 kb | Distal (>10kb) Multiome | 253 | |
| chr10:110,833,606–110,834,169 | 85.8 kb | Distal (>10kb) Multiome | 160 | |
| chr10:110,857,173–110,858,770 | 62.0 kb | Distal (>10kb) Multiome | 690 | |
| chr10:110,871,026–110,872,969 | 47.8 kb | Distal (>10kb) Multiome | 918 | |
| chr10:110,918,245–110,920,897 | 224 bp | At TSS Multiome | 1037 | |
| chr10:111,075,793–111,079,438 | 156.8 kb | Distal (>10kb) Multiome | 555 | |
| chr10:111,136,785–111,137,423 | 217.5 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the SHOC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.