Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHISA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHISA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHISA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:25,776,523–25,777,053 | 275.2 kb | Distal (>10kb) Multiome | 82 | |
| chr13:25,910,243–25,911,765 | 141.6 kb | Distal (>10kb) Multiome HiCAR | 243 | |
| chr13:25,977,016–25,977,600 | 74.7 kb | Distal (>10kb) Multiome | 163 | |
| chr13:25,977,740–25,978,960 | 73.5 kb | Distal (>10kb) Multiome | 191 | |
| chr13:26,050,068–26,052,550 | 50 bp | At TSS Multiome | 468 | |
| chr13:26,186,100–26,186,936 | 134.6 kb | Distal (>10kb) Multiome | 821 | |
| chr13:26,221,461–26,222,628 | 169.9 kb | Distal (>10kb) Multiome | 979 | |
| chr13:26,253,747–26,254,977 | 202.1 kb | Distal (>10kb) Multiome | 742 |
Genomic view of the SHISA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.