Enables phosphotyrosine residue binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:88,990,709–88,991,952 | 187.5 kb | Distal (>10kb) Multiome | 388 | |
| chr9:89,177,494–89,178,865 | at TSS | At TSS | 232 | |
| chr9:89,179,706–89,180,739 | 1.6 kb | Proximal (<10kb) Multiome | 598 | |
| chr9:89,186,113–89,186,284 | 7.3 kb | Proximal (<10kb) | 69 | |
| chr9:89,225,983–89,226,479 | 47.5 kb | Distal (>10kb) Multiome | 72 | |
| chr9:89,310,238–89,311,866 | 132.2 kb | Distal (>10kb) Multiome | 945 | |
| chr9:89,317,972–89,319,093 | 139.8 kb | Distal (>10kb) Multiome | 1083 | |
| chr9:89,435,291–89,435,862 | 256.7 kb | Distal (>10kb) Multiome | 216 |
Genomic view of the SHC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.