SHC1

SHC adaptor protein 1 | ShcA, p66, SHC

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Biological processes 41 terms

Shc-EGFR complex (GO:0070435)cellular response to growth factor stimulus (GO:0071363)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)defense response to bacterium (GO:0042742)ephrin receptor binding (GO:0046875)ephrin receptor binding (GO:0046875)epidermal growth factor binding (GO:0048408)epidermal growth factor receptor binding (GO:0005154)epidermal growth factor receptor signaling pathway (GO:0007173)epidermal growth factor receptor signaling pathway (GO:0007173)focal adhesion (GO:0005925)insulin receptor binding (GO:0005158)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)insulin-like growth factor receptor binding (GO:0005159)insulin-like growth factor receptor signaling pathway (GO:0048009)intracellular signal transduction (GO:0035556)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of angiogenesis (GO:0016525)negative regulation of apoptotic process (GO:0043066)neurotrophin TRKA receptor binding (GO:0005168)phospholipid binding (GO:0005543)phosphotyrosine residue binding (GO:0001784)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of MAPK cascade (GO:0043410)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell proliferation in bone marrow (GO:0071864)protein binding (GO:0005515)receptor tyrosine kinase binding (GO:0030971)receptor tyrosine kinase binding (GO:0030971)regulation of superoxide metabolic process (GO:0090322)transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068)transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068)

Expression (TPM)

TFs regulating SHC1 0 TFs

Transcription factors with Perturb-seq knockdown data for SHC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SHC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:154,683,607–154,684,346	290.3 kb	Distal (>10kb) Multiome	39
chr1:154,760,465–154,760,941	213.7 kb	Distal (>10kb) Multiome	418
chr1:154,813,354–154,814,052	160.7 kb	Distal (>10kb) Multiome	189
chr1:154,870,031–154,870,680	104.0 kb	Distal (>10kb) Multiome	300
chr1:154,936,148–154,937,752	37.4 kb	Distal (>10kb) Multiome	1149
chr1:154,955,571–154,956,925	18.2 kb	Distal (>10kb) Multiome	504
chr1:154,961,269–154,962,529	12.6 kb	Distal (>10kb) Multiome	985
chr1:154,970,161–154,971,641	3.5 kb	Proximal (<10kb) Multiome	535
chr1:154,972,362–154,975,914	215 bp	At TSS Multiome	1085
chr1:154,982,968–154,983,632	8.9 kb	Proximal (<10kb) Multiome	693
chr1:154,998,961–155,004,423	24.9 kb	Distal (>10kb) Multiome	1210
chr1:155,017,084–155,017,941	43.1 kb	Distal (>10kb) Multiome	1003
chr1:155,050,292–155,052,078	76.9 kb	Distal (>10kb) Multiome	948
chr1:155,061,415–155,064,552	89.5 kb	Distal (>10kb) Multiome	860
chr1:155,070,748–155,071,423	96.7 kb	Distal (>10kb) Multiome	542
chr1:155,078,524–155,079,535	104.4 kb	Distal (>10kb) Multiome	397
chr1:155,079,852–155,081,529	106.6 kb	Distal (>10kb) Multiome	539
chr1:155,084,373–155,086,501	110.7 kb	Distal (>10kb) Multiome	865
chr1:155,091,315–155,091,900	117.2 kb	Distal (>10kb) Multiome	594
chr1:155,126,247–155,126,903	152.1 kb	Distal (>10kb) Multiome	776
chr1:155,127,607–155,128,120	153.5 kb	Distal (>10kb) Multiome	578
chr1:155,135,100–155,136,750	161.5 kb	Distal (>10kb) Multiome	938
chr1:155,166,847–155,168,170	193.4 kb	Distal (>10kb) Multiome	622
chr1:155,172,629–155,174,979	198.9 kb	Distal (>10kb) Multiome	903
chr1:155,192,921–155,194,099	219.2 kb	Distal (>10kb) Multiome	755
chr1:155,194,230–155,195,403	220.5 kb	Distal (>10kb) Multiome	753
chr1:155,196,127–155,196,592	222.0 kb	Distal (>10kb) Multiome	97
chr1:155,207,822–155,209,789	234.6 kb	Distal (>10kb) Multiome	826
chr1:155,226,522–155,227,197	252.2 kb	Distal (>10kb) Multiome	600
chr1:155,227,312–155,228,116	253.3 kb	Distal (>10kb) Multiome	688
chr1:155,244,103–155,245,349	270.4 kb	Distal (>10kb) Multiome	900
chr1:155,250,356–155,251,199	276.5 kb	Distal (>10kb) Multiome	605
chr1:155,255,032–155,255,921	281.2 kb	Distal (>10kb) Multiome	661
chr1:155,261,679–155,262,788	288.0 kb	Distal (>10kb) Multiome	921
chr1:155,272,928–155,274,098	299.1 kb	Distal (>10kb) Multiome	768

Genome Browser

Genomic view of the SHC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.