This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for SH3GLB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3GLB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3GLB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:86,501,812–86,504,473 | 201.7 kb | Distal (>10kb) Multiome HiCAR | 332 | |
| chr1:86,703,797–86,705,777 | 104 bp | At TSS Multiome | 1030 | |
| chr1:86,755,319–86,756,660 | 51.4 kb | Distal (>10kb) Multiome | 183 | |
| chr1:86,823,769–86,824,525 | 119.5 kb | Distal (>10kb) Multiome | 408 | |
| chr1:86,913,509–86,916,034 | 210.0 kb | Distal (>10kb) Multiome | 926 |
Genomic view of the SH3GLB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.