Enables identical protein binding activity. Predicted to be involved in central nervous system development and signal transduction. Predicted to be located in acrosomal vesicle and early endosome membrane. Predicted to be part of early endosome. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SH3GL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3GL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3GL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:83,178,820–83,179,295 | 268.3 kb | Distal (>10kb) Multiome | 114 | |
| chr15:83,206,651–83,208,545 | 239.1 kb | Distal (>10kb) Multiome | 607 | |
| chr15:83,378,916–83,379,702 | 68.1 kb | Distal (>10kb) Multiome | 191 | |
| chr15:83,438,592–83,438,965 | 8.4 kb | Proximal (<10kb) | 130 | |
| chr15:83,446,671–83,448,301 | 13 bp | At TSS Multiome | 542 | |
| chr15:83,449,286–83,449,612 | 1.9 kb | Proximal (<10kb) | 62 | |
| chr15:83,653,213–83,655,246 | 206.6 kb | Distal (>10kb) Multiome | 363 |
Genomic view of the SH3GL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.