This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for SH3D19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3D19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3D19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:151,048,986–151,049,930 | 276.0 kb | Distal (>10kb) Multiome | 85 | |
| chr4:151,092,530–151,093,186 | 232.8 kb | Distal (>10kb) Multiome | 32 | |
| chr4:151,098,977–151,100,295 | 226.1 kb | Distal (>10kb) Multiome | 1069 | |
| chr4:151,324,320–151,326,042 | 1.1 kb | Proximal (<10kb) Multiome | 942 | |
| chr4:151,407,549–151,410,460 | 83.4 kb | Distal (>10kb) Multiome | 800 | |
| chr4:151,488,949–151,490,034 | 164.0 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the SH3D19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.