Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in JNK cascade. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH2D3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH2D3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH2D3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,458,960–6,460,940 | 307.1 kb | Distal (>10kb) Multiome HiCAR | 859 | |
| chr19:6,470,903–6,471,589 | 296.2 kb | Distal (>10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 290.9 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 251.3 kb | Distal (>10kb) Multiome HiCAR | 732 | |
| chr19:6,530,842–6,531,584 | 236.5 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 215.4 kb | Distal (>10kb) Multiome | 403 | |
| chr19:6,656,104–6,656,671 | 111.0 kb | Distal (>10kb) Multiome | 10 | |
| chr19:6,661,103–6,661,799 | 105.9 kb | Distal (>10kb) Multiome | 83 | |
| chr19:6,718,413–6,719,236 | 48.5 kb | Distal (>10kb) Multiome | 284 | |
| chr19:6,729,971–6,731,015 | 36.8 kb | Distal (>10kb) Multiome | 470 | |
| chr19:6,736,423–6,741,197 | 29.8 kb | Distal (>10kb) Multiome | 1129 | |
| chr19:6,752,403–6,754,362 | 13.7 kb | Distal (>10kb) Multiome | 886 | |
| chr19:6,765,980–6,766,368 | 1.1 kb | Proximal (<10kb) | 295 | |
| chr19:6,767,097–6,768,193 | 179 bp | At TSS Multiome | 549 |
Genomic view of the SH2D3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.