Transcription factors with Perturb-seq knockdown data for SGO1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGO1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGO1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:19,946,276–19,948,278 | 239.3 kb | Distal (>10kb) Multiome | 1049 | |
| chr3:20,039,710–20,041,964 | 146.1 kb | Distal (>10kb) Multiome | 939 | |
| chr3:20,185,379–20,186,994 | 64 bp | At TSS Multiome | 897 | |
| chr3:20,191,087–20,191,287 | 4.7 kb | Proximal (<10kb) | 44 | |
| chr3:20,329,612–20,330,683 | 143.8 kb | Distal (>10kb) Multiome | 321 | |
| chr3:21,728,994–21,730,158 | 1543.2 kb | Distal (>10kb) Multiome HiCAR | 118 |
Genomic view of the SGO1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.