This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for SFXN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFXN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFXN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,022,769–119,023,594 | 142.5 kb | Distal (>10kb) Multiome | 196 | |
| chr10:119,028,784–119,030,985 | 136.2 kb | Distal (>10kb) Multiome | 776 | |
| chr10:119,080,039–119,081,458 | 84.8 kb | Distal (>10kb) Multiome | 953 | |
| chr10:119,092,145–119,092,653 | 73.2 kb | Distal (>10kb) Multiome | 103 | |
| chr10:119,103,400–119,104,998 | 61.6 kb | Distal (>10kb) Multiome | 607 | |
| chr10:119,140,467–119,141,205 | 24.7 kb | Distal (>10kb) Multiome | 164 | |
| chr10:119,165,095–119,166,223 | 9 bp | At TSS Multiome | 815 | |
| chr10:119,174,180–119,174,409 | 8.5 kb | Proximal (<10kb) | 27 | |
| chr10:119,178,426–119,179,231 | 13.1 kb | Distal (>10kb) Multiome | 801 | |
| chr10:119,206,342–119,208,274 | 41.7 kb | Distal (>10kb) Multiome | 780 |
Genomic view of the SFXN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.