Enables L-alanine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in L-alanine transport; L-serine transport; and serine import into mitochondrion. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SFXN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFXN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFXN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:174,910,260–174,910,733 | 568.1 kb | Distal (>10kb) Multiome HiCAR | 200 | |
| chr5:175,443,902–175,445,629 | 33.8 kb | Distal (>10kb) Multiome | 291 | |
| chr5:175,447,194–175,447,921 | 30.9 kb | Distal (>10kb) Multiome | 49 | |
| chr5:175,478,159–175,479,153 | 13 bp | At TSS Multiome | 710 | |
| chr5:175,533,977–175,534,736 | 55.7 kb | Distal (>10kb) Multiome | 438 | |
| chr5:175,657,660–175,658,971 | 179.5 kb | Distal (>10kb) Multiome | 283 | |
| chr5:175,688,357–175,689,084 | 210.2 kb | Distal (>10kb) Multiome | 66 | |
| chr5:175,729,513–175,730,170 | 251.4 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the SFXN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.