Predicted to be involved in protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including cytoplasm; endomembrane system; and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SFT2D3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFT2D3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFT2D3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,407,631–127,408,983 | 293.3 kb | Distal (>10kb) Multiome | 878 | |
| chr2:127,415,703–127,416,595 | 285.4 kb | Distal (>10kb) Multiome | 501 | |
| chr2:127,422,503–127,423,812 | 278.2 kb | Distal (>10kb) Multiome | 321 | |
| chr2:127,463,310–127,464,007 | 237.8 kb | Distal (>10kb) Multiome | 176 | |
| chr2:127,525,984–127,528,084 | 174.9 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:127,542,311–127,543,476 | 158.3 kb | Distal (>10kb) Multiome | 233 | |
| chr2:127,591,279–127,591,967 | 109.9 kb | Distal (>10kb) Multiome | 431 | |
| chr2:127,674,653–127,675,849 | 26.2 kb | Distal (>10kb) Multiome | 324 | |
| chr2:127,695,779–127,695,971 | 5.5 kb | Proximal (<10kb) | 144 | |
| chr2:127,700,417–127,702,395 | 42 bp | At TSS Multiome | 1115 | |
| chr2:127,810,532–127,811,650 | 109.7 kb | Distal (>10kb) Multiome | 948 | |
| chr2:127,857,714–127,858,658 | 156.7 kb | Distal (>10kb) Multiome | 924 | |
| chr2:127,859,716–127,860,274 | 158.4 kb | Distal (>10kb) Multiome | 286 | |
| chr2:127,885,860–127,886,795 | 184.8 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the SFT2D3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.