This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for SFSWAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFSWAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFSWAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:131,623,903–131,626,152 | 85.8 kb | Distal (>10kb) Multiome | 286 | |
| chr12:131,682,187–131,682,744 | 28.7 kb | Distal (>10kb) Multiome | 150 | |
| chr12:131,710,558–131,711,365 | 166 bp | At TSS Multiome | 947 | |
| chr12:131,827,942–131,828,736 | 117.3 kb | Distal (>10kb) Multiome | 309 | |
| chr12:131,830,019–131,831,053 | 119.5 kb | Distal (>10kb) Multiome | 495 | |
| chr12:131,894,077–131,895,155 | 183.4 kb | Distal (>10kb) Multiome | 460 | |
| chr12:131,895,483–131,896,833 | 185.2 kb | Distal (>10kb) Multiome | 784 | |
| chr12:131,928,499–131,930,478 | 218.0 kb | Distal (>10kb) Multiome | 908 | |
| chr12:131,949,435–131,950,660 | 238.8 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the SFSWAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.