This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for SFRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:41,276,067–41,276,631 | 33.0 kb | Distal (>10kb) Multiome | 97 | |
| chr8:41,306,471–41,306,855 | 2.6 kb | Proximal (<10kb) | 71 | |
| chr8:41,307,746–41,308,094 | 1.4 kb | Proximal (<10kb) | 87 | |
| chr8:41,308,199–41,310,004 | 30 bp | At TSS Multiome | 268 | |
| chr8:41,310,565–41,311,994 | 1.1 kb | Proximal (<10kb) | 101 | |
| chr8:41,312,392–41,312,956 | 2.9 kb | Proximal (<10kb) | 38 | |
| chr8:41,341,689–41,343,004 | 32.9 kb | Distal (>10kb) Multiome | 138 | |
| chr8:41,360,734–41,361,748 | 51.7 kb | Distal (>10kb) Multiome | 214 | |
| chr8:41,489,933–41,491,073 | 181.0 kb | Distal (>10kb) Multiome | 716 | |
| chr8:41,528,584–41,529,537 | 219.6 kb | Distal (>10kb) Multiome | 730 | |
| chr8:41,567,337–41,567,862 | 258.0 kb | Distal (>10kb) Multiome | 108 | |
| chr8:41,577,579–41,578,739 | 268.7 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the SFRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.