Enables histone binding activity. Involved in negative regulation of gene expression. Located in aggresome; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SFMBT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFMBT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFMBT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:7,406,757–7,407,705 | 1.6 kb | Proximal (<10kb) | 163 | |
| chr10:7,407,757–7,409,381 | 2.9 kb | Proximal (<10kb) Multiome | 452 | |
| chr10:7,410,337–7,413,433 | 540 bp | At TSS Multiome | 551 | |
| chr10:7,466,885–7,467,532 | 55.8 kb | Distal (>10kb) Multiome | 76 | |
| chr10:7,513,605–7,514,402 | 102.6 kb | Distal (>10kb) Multiome | 112 | |
| chr10:7,540,399–7,542,174 | 129.4 kb | Distal (>10kb) Multiome | 420 | |
| chr10:7,551,477–7,552,685 | 140.6 kb | Distal (>10kb) Multiome | 160 | |
| chr10:7,605,258–7,606,229 | 194.3 kb | Distal (>10kb) Multiome | 80 | |
| chr10:7,618,865–7,620,103 | 208.1 kb | Distal (>10kb) Multiome | 246 | |
| chr10:7,667,487–7,668,354 | 256.2 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the SFMBT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.