This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for SFMBT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFMBT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFMBT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,770,467–52,771,332 | 275.8 kb | Distal (>10kb) Multiome | 788 | |
| chr3:52,897,094–52,897,995 | 149.1 kb | Distal (>10kb) Multiome | 474 | |
| chr3:53,044,987–53,047,058 | 1.2 kb | Proximal (<10kb) Multiome | 653 | |
| chr3:53,051,973–53,052,307 | 5.9 kb | Proximal (<10kb) | 35 | |
| chr3:53,072,497–53,073,757 | 26.3 kb | Distal (>10kb) Multiome | 597 | |
| chr3:53,130,008–53,130,811 | 83.8 kb | Distal (>10kb) Multiome | 781 | |
| chr3:53,160,572–53,162,503 | 114.3 kb | Distal (>10kb) Multiome | 627 | |
| chr3:53,216,604–53,217,511 | 170.3 kb | Distal (>10kb) Multiome | 92 | |
| chr3:53,219,753–53,220,316 | 173.4 kb | Distal (>10kb) Multiome | 367 | |
| chr3:53,254,585–53,256,437 | 209.4 kb | Distal (>10kb) Multiome | 773 | |
| chr3:53,269,991–53,270,526 | 223.6 kb | Distal (>10kb) Multiome | 744 |
Genomic view of the SFMBT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.