SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SETD1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,536,039–121,536,480 | 267.7 kb | Distal (>10kb) Multiome | 262 | |
| chr12:121,576,794–121,577,632 | 226.9 kb | Distal (>10kb) Multiome | 171 | |
| chr12:121,580,160–121,581,909 | 223.6 kb | Distal (>10kb) Multiome | 629 | |
| chr12:121,582,525–121,583,038 | 221.2 kb | Distal (>10kb) Multiome | 309 | |
| chr12:121,625,878–121,627,559 | 177.5 kb | Distal (>10kb) Multiome | 904 | |
| chr12:121,671,731–121,673,334 | 131.4 kb | Distal (>10kb) Multiome | 548 | |
| chr12:121,686,676–121,687,782 | 116.9 kb | Distal (>10kb) Multiome | 907 | |
| chr12:121,712,130–121,713,412 | 91.2 kb | Distal (>10kb) Multiome | 731 | |
| chr12:121,792,642–121,795,650 | 9.9 kb | Proximal (<10kb) Multiome | 1009 | |
| chr12:121,797,071–121,801,369 | 5.4 kb | Proximal (<10kb) Multiome | 1126 | |
| chr12:121,802,658–121,804,393 | 893 bp | At TSS Multiome | 825 | |
| chr12:121,811,362–121,812,315 | 7.4 kb | Proximal (<10kb) | 645 | |
| chr12:121,812,380–121,813,114 | 8.4 kb | Proximal (<10kb) Multiome HiCAR | 458 | |
| chr12:121,839,137–121,840,260 | 35.6 kb | Distal (>10kb) Multiome | 564 | |
| chr12:121,888,344–121,889,335 | 84.8 kb | Distal (>10kb) Multiome HiCAR | 1141 | |
| chr12:121,918,184–121,919,001 | 114.6 kb | Distal (>10kb) Multiome | 407 | |
| chr12:122,021,348–122,022,698 | 218.0 kb | Distal (>10kb) Multiome | 537 | |
| chr12:122,063,787–122,064,537 | 260.2 kb | Distal (>10kb) Multiome | 742 | |
| chr12:122,064,878–122,065,312 | 261.2 kb | Distal (>10kb) Multiome | 355 | |
| chr12:122,078,081–122,079,394 | 274.6 kb | Distal (>10kb) Multiome | 952 | |
| chr12:122,097,641–122,098,611 | 294.0 kb | Distal (>10kb) Multiome | 462 |
Genomic view of the SETD1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.