This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for SESN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SESN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SESN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:108,781,208–108,782,610 | 228.0 kb | Distal (>10kb) Multiome | 561 | |
| chr6:108,838,106–108,838,816 | 171.2 kb | Distal (>10kb) Multiome | 212 | |
| chr6:108,847,848–108,848,955 | 161.1 kb | Distal (>10kb) Multiome | 734 | |
| chr6:109,008,977–109,009,970 | 1 bp | At TSS Multiome | 785 | |
| chr6:109,094,199–109,095,904 | 85.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr6:109,186,108–109,187,056 | 176.9 kb | Distal (>10kb) Multiome | 39 | |
| chr6:109,236,275–109,236,762 | 227.0 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the SESN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.