SERINC3

serine incorporator 3 | AIGP1, DIFF33, SBBI99, TDE, TMS-1, TDE1

Enables phospholipid scramblase activity. Involved in antiviral innate immune response and plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 Developmental clusters: GC7

Biological processes 14 terms

Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)L-serine metabolic process (GO:0006563)antiviral innate immune response (GO:0140374)membrane (GO:0016020)membrane (GO:0016020)molecular carrier activity (GO:0140104)perinuclear region of cytoplasm (GO:0048471)phospholipid scramblase activity (GO:0017128)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane phospholipid scrambling (GO:0017121)protein binding (GO:0005515)

Expression (TPM)

TFs regulating SERINC3 0 TFs

Transcription factors with Perturb-seq knockdown data for SERINC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERINC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SERINC3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERINC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:44,310,737–44,311,623	210.8 kb	Distal (>10kb) Multiome	908
chr20:44,475,692–44,476,318	46.2 kb	Distal (>10kb) Multiome	962
chr20:44,521,574–44,522,457	40 bp	At TSS Multiome	937
chr20:44,522,935–44,523,165	881 bp	At TSS	24
chr20:44,523,577–44,525,342	2.9 kb	Proximal (<10kb) Multiome	231
chr20:44,531,682–44,532,180	9.8 kb	Proximal (<10kb) Multiome	880
chr20:44,609,775–44,610,281	88.1 kb	Distal (>10kb) Multiome HiCAR	727
chr20:44,642,246–44,643,140	120.6 kb	Distal (>10kb) Multiome	469
chr20:44,651,099–44,652,334	129.8 kb	Distal (>10kb) Multiome	641
chr20:44,745,652–44,746,316	223.9 kb	Distal (>10kb) Multiome	321
chr20:44,810,403–44,810,885	288.5 kb	Distal (>10kb) Multiome	181

Genome Browser

Genomic view of the SERINC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.