This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEPTIN6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:119,399,020–119,399,773 | 293.7 kb | Distal (>10kb) Multiome | 440 | |
| chrX:119,468,031–119,469,511 | 224.8 kb | Distal (>10kb) Multiome | 762 | |
| chrX:119,573,862–119,575,243 | 118.6 kb | Distal (>10kb) Multiome | 734 | |
| chrX:119,605,775–119,606,635 | 86.7 kb | Distal (>10kb) Multiome | 518 | |
| chrX:119,692,568–119,693,792 | 177 bp | At TSS Multiome | 595 | |
| chrX:119,697,965–119,698,301 | 4.8 kb | Proximal (<10kb) | 11 | |
| chrX:119,698,773–119,699,112 | 5.6 kb | Proximal (<10kb) | 115 | |
| chrX:119,757,760–119,759,432 | 65.1 kb | Distal (>10kb) Multiome | 507 | |
| chrX:119,791,353–119,792,197 | 98.6 kb | Distal (>10kb) Multiome | 699 | |
| chrX:119,852,659–119,853,400 | 159.9 kb | Distal (>10kb) Multiome | 612 | |
| chrX:119,871,438–119,872,306 | 178.7 kb | Distal (>10kb) Multiome | 720 | |
| chrX:119,943,211–119,943,921 | 250.5 kb | Distal (>10kb) Multiome | 763 |
Genomic view of the SEPTIN6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.