SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for SENP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SENP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SENP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:185,282,769–185,283,294 | 299.5 kb | Distal (>10kb) Multiome | 660 | |
| chr3:185,372,493–185,373,188 | 209.8 kb | Distal (>10kb) Multiome | 60 | |
| chr3:185,498,399–185,499,479 | 83.5 kb | Distal (>10kb) Multiome | 1024 | |
| chr3:185,575,488–185,575,708 | 6.8 kb | Proximal (<10kb) | 147 | |
| chr3:185,581,887–185,582,879 | 165 bp | At TSS Multiome | 125 | |
| chr3:185,585,767–185,586,789 | 3.7 kb | Proximal (<10kb) Multiome | 851 | |
| chr3:185,786,185–185,786,786 | 204.0 kb | Distal (>10kb) Multiome | 166 | |
| chr3:185,824,058–185,826,626 | 242.8 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the SENP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.