Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEMA4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEMA4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEMA4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,637,810–96,638,901 | 231.8 kb | Distal (>10kb) Multiome | 1144 | |
| chr2:96,739,549–96,740,363 | 130.0 kb | Distal (>10kb) Multiome | 708 | |
| chr2:96,760,354–96,761,531 | 109.2 kb | Distal (>10kb) Multiome | 776 | |
| chr2:96,762,598–96,764,653 | 107.0 kb | Distal (>10kb) Multiome | 406 | |
| chr2:96,815,434–96,817,859 | 53.8 kb | Distal (>10kb) Multiome | 926 | |
| chr2:96,857,099–96,859,416 | 11.9 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:96,868,320–96,870,552 | 35 bp | At TSS Multiome | 907 | |
| chr2:96,875,469–96,875,792 | 6.9 kb | Proximal (<10kb) | 101 | |
| chr2:96,881,325–96,881,826 | 11.6 kb | Distal (>10kb) Multiome | 188 | |
| chr2:96,951,012–96,951,489 | 81.2 kb | Distal (>10kb) Multiome HiCAR | 450 |
Genomic view of the SEMA4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.