This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for SELENOT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:150,407,694–150,411,095 | 194.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr3:150,545,562–150,547,264 | 56.7 kb | Distal (>10kb) Multiome | 992 | |
| chr3:150,599,511–150,600,247 | 3.4 kb | Proximal (<10kb) Multiome | 405 | |
| chr3:150,602,900–150,604,229 | 10 bp | At TSS Multiome | 999 | |
| chr3:150,607,417–150,607,924 | 4.1 kb | Proximal (<10kb) | 82 | |
| chr3:150,703,274–150,704,319 | 100.6 kb | Distal (>10kb) Multiome | 674 | |
| chr3:150,762,327–150,764,149 | 160.0 kb | Distal (>10kb) Multiome | 953 |
Genomic view of the SELENOT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.