The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEC61G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC61G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC61G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:54,546,040–54,547,281 | 212.3 kb | Distal (>10kb) Multiome | 376 | |
| chr7:54,663,850–54,665,461 | 94.7 kb | Distal (>10kb) Multiome | 474 | |
| chr7:54,758,708–54,760,017 | 37 bp | At TSS Multiome | 824 | |
| chr7:54,932,927–54,933,551 | 174.1 kb | Distal (>10kb) Multiome | 296 | |
| chr7:55,018,217–55,020,474 | 259.9 kb | Distal (>10kb) Multiome | 537 | |
| chr7:55,254,293–55,256,212 | 496.5 kb | Distal (>10kb) Multiome HiCAR | 743 |
Genomic view of the SEC61G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.