This lncRNA contains a single Alu element which, along with 1/2-sbsRNA3, appears to target the 3' UTR Alu element in MTAP. Downregulation of the RNA appears to up-regulate the target. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for SEC24B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC24B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC24B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:109,301,583–109,303,714 | 130.9 kb | Distal (>10kb) Multiome | 426 | |
| chr4:109,375,427–109,376,315 | 57.9 kb | Distal (>10kb) Multiome | 86 | |
| chr4:109,386,823–109,387,310 | 46.8 kb | Distal (>10kb) Multiome | 74 | |
| chr4:109,419,054–109,420,658 | 14.0 kb | Distal (>10kb) Multiome | 227 | |
| chr4:109,433,232–109,434,512 | 69 bp | At TSS Multiome | 802 | |
| chr4:109,435,869–109,436,805 | 2.1 kb | Proximal (<10kb) | 99 | |
| chr4:109,559,632–109,561,390 | 126.4 kb | Distal (>10kb) Multiome | 756 | |
| chr4:109,701,412–109,703,899 | 269.6 kb | Distal (>10kb) Multiome | 799 | |
| chr4:109,729,247–109,730,761 | 296.3 kb | Distal (>10kb) Multiome | 793 | |
| chr4:109,814,867–109,816,081 | 381.7 kb | Distal (>10kb) Multiome HiCAR | 846 |
Genomic view of the SEC24B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.