The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for SEC24A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC24A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC24A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:134,366,722–134,367,362 | 281.6 kb | Distal (>10kb) Multiome | 682 | |
| chr5:134,370,722–134,372,303 | 277.5 kb | Distal (>10kb) Multiome | 1080 | |
| chr5:134,411,465–134,412,433 | 236.8 kb | Distal (>10kb) Multiome | 989 | |
| chr5:134,465,626–134,467,213 | 182.8 kb | Distal (>10kb) Multiome | 926 | |
| chr5:134,506,114–134,506,990 | 142.4 kb | Distal (>10kb) Multiome | 644 | |
| chr5:134,511,761–134,512,800 | 136.5 kb | Distal (>10kb) Multiome | 505 | |
| chr5:134,523,964–134,528,361 | 121.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr5:134,539,671–134,540,206 | 108.9 kb | Distal (>10kb) Multiome | 144 | |
| chr5:134,586,828–134,587,543 | 61.6 kb | Distal (>10kb) Multiome | 407 | |
| chr5:134,632,348–134,633,007 | 16.0 kb | Distal (>10kb) Multiome | 1019 | |
| chr5:134,648,377–134,649,305 | 16 bp | At TSS Multiome | 995 | |
| chr5:134,737,780–134,739,410 | 89.6 kb | Distal (>10kb) Multiome | 1014 | |
| chr5:134,758,294–134,759,262 | 109.9 kb | Distal (>10kb) Multiome | 1011 | |
| chr5:134,845,740–134,846,572 | 197.2 kb | Distal (>10kb) Multiome | 923 | |
| chr5:134,873,977–134,874,865 | 225.6 kb | Distal (>10kb) Multiome | 978 | |
| chr5:134,904,363–134,905,880 | 256.1 kb | Distal (>10kb) Multiome | 1005 |
Genomic view of the SEC24A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.