This gene encodes a member of the SEC22 family of vesicle trafficking proteins. The encoded protein is localized to the endoplasmic reticulum and may play a role in the early stages of ER-Golgi protein trafficking. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for SEC22C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC22C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC22C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:42,349,668–42,350,325 | 232.0 kb | Distal (>10kb) Multiome | 246 | |
| chr3:42,446,025–42,446,484 | 135.7 kb | Distal (>10kb) Multiome | 27 | |
| chr3:42,501,285–42,503,228 | 79.4 kb | Distal (>10kb) Multiome | 508 | |
| chr3:42,539,796–42,540,344 | 41.9 kb | Distal (>10kb) Multiome | 180 | |
| chr3:42,572,368–42,572,618 | 9.3 kb | Proximal (<10kb) | 153 | |
| chr3:42,581,475–42,582,842 | 121 bp | At TSS Multiome | 889 | |
| chr3:42,590,205–42,591,365 | 8.8 kb | Proximal (<10kb) Multiome | 646 | |
| chr3:42,600,083–42,601,438 | 18.7 kb | Distal (>10kb) Multiome | 914 | |
| chr3:42,653,440–42,655,446 | 72.7 kb | Distal (>10kb) Multiome | 631 | |
| chr3:42,772,623–42,773,428 | 191.3 kb | Distal (>10kb) Multiome | 446 | |
| chr3:42,803,822–42,804,944 | 222.6 kb | Distal (>10kb) Multiome | 881 | |
| chr3:42,805,298–42,806,226 | 224.0 kb | Distal (>10kb) Multiome | 381 | |
| chr3:42,880,478–42,881,506 | 299.2 kb | Distal (>10kb) Multiome | 685 |
Genomic view of the SEC22C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.