The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for SEC22A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC22A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC22A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:122,942,761–122,943,436 | 258.9 kb | Distal (>10kb) Multiome | 336 | |
| chr3:122,975,104–122,975,992 | 226.4 kb | Distal (>10kb) Multiome | 338 | |
| chr3:123,026,031–123,028,771 | 174.1 kb | Distal (>10kb) Multiome | 478 | |
| chr3:123,066,643–123,067,789 | 134.9 kb | Distal (>10kb) Multiome | 865 | |
| chr3:123,080,786–123,081,476 | 121.0 kb | Distal (>10kb) Multiome | 291 | |
| chr3:123,081,598–123,082,265 | 119.9 kb | Distal (>10kb) Multiome | 186 | |
| chr3:123,143,533–123,144,461 | 57.9 kb | Distal (>10kb) Multiome | 294 | |
| chr3:123,169,519–123,169,980 | 32.2 kb | Distal (>10kb) Multiome | 64 | |
| chr3:123,194,557–123,194,960 | 7.0 kb | Proximal (<10kb) | 182 | |
| chr3:123,201,446–123,202,796 | 85 bp | At TSS Multiome | 651 | |
| chr3:123,314,223–123,315,571 | 113.1 kb | Distal (>10kb) Multiome | 264 | |
| chr3:123,447,574–123,450,476 | 246.1 kb | Distal (>10kb) Multiome | 427 |
Genomic view of the SEC22A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.