The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for SDHAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDHAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDHAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,702,152–35,702,985 | 292.7 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 277.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 254.4 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 249.9 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 246.7 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 237.1 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 227.2 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 219.7 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 210.5 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 133.9 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 126.7 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 125.2 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 95.5 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 63.5 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 58.8 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 8.0 kb | Proximal (<10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 25 bp | At TSS Multiome | 897 | |
| chr19:36,013,972–36,014,810 | 19.2 kb | Distal (>10kb) Multiome | 623 | |
| chr19:36,032,424–36,033,187 | 37.7 kb | Distal (>10kb) Multiome | 179 | |
| chr19:36,053,782–36,055,591 | 59.3 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:36,113,981–36,116,196 | 120.2 kb | Distal (>10kb) Multiome | 1052 | |
| chr19:36,127,575–36,128,707 | 132.8 kb | Distal (>10kb) Multiome | 942 | |
| chr19:36,139,425–36,141,811 | 144.7 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:36,214,162–36,215,543 | 219.7 kb | Distal (>10kb) Multiome | 1008 | |
| chr19:36,245,106–36,245,849 | 250.3 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the SDHAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.