Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SDAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:75,704,833–75,705,758 | 285.5 kb | Distal (>10kb) Multiome | 191 | |
| chr4:75,723,996–75,725,607 | 266.4 kb | Distal (>10kb) Multiome | 996 | |
| chr4:75,848,100–75,848,739 | 142.5 kb | Distal (>10kb) Multiome | 281 | |
| chr4:75,939,639–75,941,475 | 49.9 kb | Distal (>10kb) Multiome | 762 | |
| chr4:75,990,621–75,991,159 | 4 bp | At TSS Multiome | 782 | |
| chr4:76,087,045–76,087,527 | 96.3 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr4:76,147,405–76,148,870 | 157.5 kb | Distal (>10kb) Multiome | 1076 | |
| chr4:76,212,911–76,214,625 | 222.8 kb | Distal (>10kb) Multiome | 798 | |
| chr4:76,251,398–76,252,255 | 260.8 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the SDAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.