Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of blood pressure and retinoic acid metabolic process. Predicted to act upstream of or within blood vessel diameter maintenance. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCPEP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCPEP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCPEP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:56,678,153–56,679,472 | 299.2 kb | Distal (>10kb) Multiome | 301 | |
| chr17:56,708,321–56,709,261 | 269.3 kb | Distal (>10kb) Multiome | 92 | |
| chr17:56,779,885–56,780,781 | 197.7 kb | Distal (>10kb) Multiome | 694 | |
| chr17:56,833,054–56,835,255 | 144.2 kb | Distal (>10kb) Multiome | 970 | |
| chr17:56,913,307–56,914,659 | 64.0 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:56,960,529–56,961,254 | 17.2 kb | Distal (>10kb) Multiome | 955 | |
| chr17:56,975,105–56,975,456 | 2.7 kb | Proximal (<10kb) | 8 | |
| chr17:56,977,708–56,978,393 | 64 bp | At TSS Multiome | 552 | |
| chr17:57,084,539–57,086,640 | 107.0 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:57,099,741–57,100,357 | 121.9 kb | Distal (>10kb) Multiome | 119 | |
| chr17:57,255,753–57,257,084 | 278.3 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the SCPEP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.