Enables identical protein binding activity. Predicted to be involved in positive regulation of hippo signaling. Predicted to act upstream of or within several processes, including face morphogenesis; fibroblast migration; and luteinization. Located in several cellular components, including cell junction; cytosol; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCHIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCHIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCHIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:159,731,318–159,731,732 | 641 bp | At TSS | 23 | |
| chr3:159,732,215–159,733,205 | at TSS | At TSS | 297 | |
| chr3:159,762,298–159,765,990 | 31.5 kb | Distal (>10kb) Multiome | 826 | |
| chr3:159,766,666–159,766,871 | 2.7 kb | Proximal (<10kb) | 87 | |
| chr3:159,775,291–159,775,841 | 43.2 kb | Distal (>10kb) Multiome | 277 | |
| chr3:159,839,632–159,840,400 | 107.6 kb | Distal (>10kb) Multiome | 356 | |
| chr3:159,988,079–159,989,451 | 256.4 kb | Distal (>10kb) Multiome | 623 |
Genomic view of the SCHIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.