Predicted to be involved in intracellular protein transport and vesicle-mediated transport. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCFD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCFD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCFD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:53,365,264–53,366,406 | 10 bp | At TSS Multiome | 747 | |
| chr4:53,375,113–53,375,690 | 9.1 kb | Proximal (<10kb) | 13 | |
| chr4:53,377,268–53,378,213 | 11.6 kb | Distal (>10kb) Multiome | 790 | |
| chr4:53,590,980–53,591,877 | 225.5 kb | Distal (>10kb) Multiome | 299 | |
| chr4:53,592,736–53,593,436 | 227.0 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the SCFD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.