This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for SCAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:47,281,636–47,283,234 | 193.2 kb | Distal (>10kb) Multiome | 941 | |
| chr3:47,380,120–47,381,966 | 95.0 kb | Distal (>10kb) Multiome | 1058 | |
| chr3:47,475,384–47,476,386 | 10 bp | At TSS Multiome | 967 | |
| chr3:47,479,322–47,479,579 | 3.4 kb | Proximal (<10kb) | 176 | |
| chr3:47,512,910–47,514,044 | 37.6 kb | Distal (>10kb) Multiome | 892 | |
| chr3:47,522,175–47,522,702 | 46.4 kb | Distal (>10kb) Multiome | 591 | |
| chr3:47,577,493–47,579,738 | 103.4 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the SCAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.