Enables UFM1-modified protein reader activity. Involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Located in intracellular membrane-bounded organelle. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SAYSD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAYSD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAYSD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:39,048,473–39,049,047 | 66.4 kb | Distal (>10kb) Multiome | 157 | |
| chr6:39,073,107–39,073,666 | 41.7 kb | Distal (>10kb) Multiome | 17 | |
| chr6:39,114,318–39,115,540 | 159 bp | At TSS Multiome | 1049 | |
| chr6:39,117,239–39,117,843 | 2.3 kb | Proximal (<10kb) Multiome | 28 | |
| chr6:39,229,044–39,229,756 | 114.4 kb | Distal (>10kb) Multiome | 626 | |
| chr6:39,303,061–39,303,638 | 188.2 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr6:39,313,260–39,314,516 | 198.5 kb | Distal (>10kb) Multiome | 156 | |
| chr6:39,362,059–39,362,807 | 247.1 kb | Distal (>10kb) Multiome | 319 |
Genomic view of the SAYSD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.