This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for SARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,402,504–38,403,738 | 527.7 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr19:38,506,710–38,507,745 | 423.5 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr19:38,514,956–38,515,568 | 415.5 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr19:38,647,137–38,648,653 | 283.2 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 264.5 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 247.1 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 195.4 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 193.7 kb | Distal (>10kb) Multiome | 493 | |
| chr19:38,754,913–38,755,455 | 175.5 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 98.9 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 78.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 60.7 kb | Distal (>10kb) Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 30.9 kb | Distal (>10kb) Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 19 bp | At TSS Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 19.2 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 46.0 kb | Distal (>10kb) Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 65.4 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 100.9 kb | Distal (>10kb) Multiome | 763 | |
| chr19:39,125,485–39,126,290 | 195.0 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the SARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.