This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for SARNP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SARNP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SARNP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,630,484–55,631,684 | 186.7 kb | Distal (>10kb) Multiome | 41 | |
| chr12:55,645,990–55,646,787 | 171.3 kb | Distal (>10kb) Multiome | 520 | |
| chr12:55,681,171–55,682,136 | 136.1 kb | Distal (>10kb) Multiome | 647 | |
| chr12:55,707,276–55,708,500 | 109.8 kb | Distal (>10kb) Multiome | 372 | |
| chr12:55,715,733–55,716,775 | 101.5 kb | Distal (>10kb) Multiome | 929 | |
| chr12:55,727,952–55,730,453 | 88.1 kb | Distal (>10kb) Multiome | 895 | |
| chr12:55,736,969–55,737,781 | 80.5 kb | Distal (>10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 79.2 kb | Distal (>10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 74.5 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 71.9 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 176 bp | At TSS Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 11.9 kb | Distal (>10kb) Multiome | 921 | |
| chr12:55,926,651–55,928,471 | 109.3 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 114.4 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 122.7 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 149.0 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 156.1 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 179.5 kb | Distal (>10kb) Multiome | 680 | |
| chr12:56,006,888–56,008,461 | 189.9 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 203.3 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 224.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 261.5 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 286.7 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 298.8 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the SARNP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.