Involved in regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SARAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SARAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SARAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,490,087–28,490,872 | 1592.7 kb | Distal (>10kb) Multiome HiCAR | 535 | |
| chr8:29,874,798–29,875,362 | 207.9 kb | Distal (>10kb) Multiome | 162 | |
| chr8:29,990,565–29,991,896 | 92.0 kb | Distal (>10kb) Multiome | 363 | |
| chr8:30,005,068–30,006,568 | 77.6 kb | Distal (>10kb) Multiome | 99 | |
| chr8:30,011,371–30,011,980 | 71.3 kb | Distal (>10kb) Multiome | 36 | |
| chr8:30,033,186–30,034,812 | 48.6 kb | Distal (>10kb) Multiome | 337 | |
| chr8:30,034,989–30,035,701 | 47.5 kb | Distal (>10kb) Multiome | 47 | |
| chr8:30,082,008–30,083,590 | 84 bp | At TSS Multiome | 1023 | |
| chr8:30,087,943–30,088,717 | 5.2 kb | Proximal (<10kb) Multiome | 89 | |
| chr8:30,094,567–30,095,766 | 12.3 kb | Distal (>10kb) Multiome | 743 | |
| chr8:30,155,587–30,157,134 | 73.3 kb | Distal (>10kb) Multiome | 798 | |
| chr8:30,227,068–30,227,925 | 144.6 kb | Distal (>10kb) Multiome | 398 | |
| chr8:30,339,419–30,340,356 | 256.7 kb | Distal (>10kb) Multiome | 302 | |
| chr8:30,382,832–30,383,366 | 299.9 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the SARAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.