Enables several functions, including non-sequence-specific DNA binding activity, bending; phosphatidylinositol phosphate binding activity; and zinc ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SAP30L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAP30L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAP30L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:153,970,477–153,971,077 | 475.3 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr5:154,085,657–154,086,553 | 359.8 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr5:154,107,450–154,108,420 | 338.0 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr5:154,150,299–154,151,127 | 295.3 kb | Distal (>10kb) Multiome | 111 | |
| chr5:154,165,484–154,166,441 | 280.0 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr5:154,167,156–154,168,295 | 278.4 kb | Distal (>10kb) Multiome HiCAR | 221 | |
| chr5:154,189,422–154,191,188 | 255.5 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr5:154,286,422–154,287,475 | 159.3 kb | Distal (>10kb) Multiome | 301 | |
| chr5:154,384,486–154,385,397 | 61.3 kb | Distal (>10kb) Multiome | 230 | |
| chr5:154,405,042–154,405,819 | 40.6 kb | Distal (>10kb) Multiome | 447 | |
| chr5:154,444,815–154,447,315 | 75 bp | At TSS Multiome | 833 | |
| chr5:154,467,573–154,468,350 | 21.9 kb | Distal (>10kb) Multiome | 289 | |
| chr5:154,472,994–154,474,261 | 27.8 kb | Distal (>10kb) Multiome | 210 | |
| chr5:154,475,660–154,476,850 | 30.4 kb | Distal (>10kb) Multiome | 158 | |
| chr5:154,477,268–154,479,654 | 32.3 kb | Distal (>10kb) Multiome | 351 | |
| chr5:154,517,158–154,517,742 | 71.4 kb | Distal (>10kb) Multiome | 176 | |
| chr5:154,520,754–154,522,246 | 75.2 kb | Distal (>10kb) Multiome | 335 | |
| chr5:154,526,303–154,527,135 | 80.9 kb | Distal (>10kb) Multiome | 36 | |
| chr5:154,610,368–154,611,194 | 164.5 kb | Distal (>10kb) Multiome HiCAR | 443 | |
| chr5:154,643,128–154,643,829 | 197.6 kb | Distal (>10kb) Multiome | 15 | |
| chr5:154,646,817–154,647,698 | 201.4 kb | Distal (>10kb) Multiome | 614 | |
| chr5:154,682,263–154,683,578 | 236.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr5:154,691,307–154,691,923 | 245.7 kb | Distal (>10kb) Multiome | 229 | |
| chr5:154,712,302–154,714,063 | 266.8 kb | Distal (>10kb) Multiome | 426 |
Genomic view of the SAP30L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.