Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SAMD4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAMD4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAMD4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,125,485–39,126,290 | 216.7 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr19:39,307,021–39,308,955 | 35.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:39,320,514–39,321,175 | 21.6 kb | Distal (>10kb) Multiome | 364 | |
| chr19:39,341,491–39,342,890 | 244 bp | At TSS Multiome | 934 | |
| chr19:39,390,544–39,391,970 | 48.7 kb | Distal (>10kb) Multiome | 1003 | |
| chr19:39,397,520–39,398,126 | 55.3 kb | Distal (>10kb) Multiome | 711 | |
| chr19:39,402,336–39,404,125 | 61.4 kb | Distal (>10kb) Multiome | 826 | |
| chr19:39,406,270–39,408,010 | 64.3 kb | Distal (>10kb) Multiome | 804 | |
| chr19:39,409,417–39,410,433 | 67.2 kb | Distal (>10kb) Multiome | 884 | |
| chr19:39,411,293–39,414,170 | 70.0 kb | Distal (>10kb) Multiome | 1109 | |
| chr19:39,428,269–39,428,993 | 86.2 kb | Distal (>10kb) Multiome | 479 | |
| chr19:39,435,526–39,436,258 | 93.6 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,445,191–39,446,019 | 103.1 kb | Distal (>10kb) Multiome | 927 | |
| chr19:39,480,241–39,481,284 | 138.3 kb | Distal (>10kb) Multiome | 880 | |
| chr19:39,497,736–39,498,430 | 155.5 kb | Distal (>10kb) Multiome | 558 | |
| chr19:39,502,647–39,503,265 | 160.5 kb | Distal (>10kb) Multiome | 835 | |
| chr19:39,506,926–39,507,691 | 164.8 kb | Distal (>10kb) Multiome | 748 | |
| chr19:39,514,761–39,515,964 | 172.8 kb | Distal (>10kb) Multiome | 370 | |
| chr19:39,532,304–39,533,247 | 190.4 kb | Distal (>10kb) Multiome | 760 | |
| chr19:39,539,469–39,540,414 | 197.7 kb | Distal (>10kb) Multiome | 772 |
Genomic view of the SAMD4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.