SALL2

spalt like transcription factor 2 | Hsal2, KIAA0360, ZNF795

This gene encodes a protein containing multiple zinc finger domains. The encoded protein functions in optical fissure closure during development of the eye in the embryo. Mutations in this gene are associated with ocular coloboma. [provided by RefSeq, Jul 2016]

Member of: DE-9 Developmental clusters: GC4

Biological processes 12 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)eye development (GO:0001654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)system development (GO:0048731)

Expression (TPM)

TFs regulating SALL2 0 TFs

Transcription factors with Perturb-seq knockdown data for SALL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SALL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SALL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SALL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:21,268,822–21,270,154	267.4 kb	Distal (>10kb) Multiome	1029
chr14:21,308,204–21,309,328	228.2 kb	Distal (>10kb) Multiome	647
chr14:21,383,896–21,384,850	152.8 kb	Distal (>10kb) Multiome	931
chr14:21,436,834–21,437,890	99.7 kb	Distal (>10kb) Multiome	875
chr14:21,455,683–21,456,683	80.9 kb	Distal (>10kb) Multiome	862
chr14:21,476,573–21,477,687	60.1 kb	Distal (>10kb) Multiome	931
chr14:21,510,804–21,511,761	25.7 kb	Distal (>10kb) Multiome	972
chr14:21,525,630–21,527,355	10.7 kb	Distal (>10kb) Multiome	627
chr14:21,534,439–21,535,312	2.3 kb	Proximal (<10kb) Multiome	146
chr14:21,536,256–21,537,359	166 bp	At TSS Multiome	181
chr14:21,557,417–21,557,905	20.5 kb	Distal (>10kb) Multiome	526

Genome Browser

Genomic view of the SALL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.