Predicted to be involved in cytoplasmic translation and positive regulation of androgen receptor activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RWDD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RWDD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RWDD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:116,279,028–116,280,325 | 291.5 kb | Distal (>10kb) Multiome HiCAR | 994 | |
| chr6:116,370,005–116,371,990 | 200.5 kb | Distal (>10kb) Multiome | 655 | |
| chr6:116,461,655–116,462,775 | 109.2 kb | Distal (>10kb) Multiome | 421 | |
| chr6:116,561,292–116,561,895 | 9.5 kb | Proximal (<10kb) | 188 | |
| chr6:116,570,743–116,571,945 | 88 bp | At TSS Multiome | 1041 | |
| chr6:116,615,808–116,617,150 | 44.9 kb | Distal (>10kb) Multiome | 493 | |
| chr6:116,668,238–116,668,984 | 97.3 kb | Distal (>10kb) Multiome | 746 | |
| chr6:116,680,569–116,682,340 | 109.7 kb | Distal (>10kb) Multiome | 965 | |
| chr6:116,764,518–116,766,081 | 194.2 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the RWDD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.