RTN4RL1

reticulon 4 receptor like 1 | DKFZp547J144, NGRH2, NgR3

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.2 Developmental clusters: GC7

Biological processes 23 terms

axon regeneration (GO:0031103)cell surface (GO:0009986)chondroitin sulfate binding (GO:0035374)chondroitin sulfate binding (GO:0035374)corpus callosum development (GO:0022038)extracellular exosome (GO:0070062)extracellular region (GO:0005576)heparin binding (GO:0008201)heparin binding (GO:0008201)membrane raft (GO:0045121)negative regulation of axon regeneration (GO:0048681)negative regulation of axon regeneration (GO:0048681)negative regulation of neuron projection development (GO:0010977)negative regulation of neuron projection development (GO:0010977)perikaryon (GO:0043204)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of synapse assembly (GO:0051965)protein binding (GO:0005515)signaling receptor activity (GO:0038023)signaling receptor activity (GO:0038023)

Expression (TPM)

TFs regulating RTN4RL1 0 TFs

Transcription factors with Perturb-seq knockdown data for RTN4RL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTN4RL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RTN4RL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTN4RL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:1,829,368–1,830,287	195.4 kb	Distal (>10kb) Multiome	660
chr17:1,931,964–1,932,566	93.0 kb	Distal (>10kb) Multiome	198
chr17:1,960,870–1,961,658	64.0 kb	Distal (>10kb) Multiome	192
chr17:1,997,556–1,998,757	27.2 kb	Distal (>10kb) Multiome	543
chr17:2,023,483–2,024,229	1.5 kb	Proximal (<10kb) Multiome	281
chr17:2,024,335–2,024,664	669 bp	At TSS	163
chr17:2,024,769–2,026,284	136 bp	At TSS Multiome	459
chr17:2,029,741–2,030,885	5.5 kb	Proximal (<10kb) Multiome	871
chr17:2,041,423–2,042,366	16.6 kb	Distal (>10kb) Multiome	834
chr17:2,048,764–2,051,218	23.7 kb	Distal (>10kb) Multiome	658
chr17:2,054,616–2,055,766	29.7 kb	Distal (>10kb) Multiome	544
chr17:2,058,401–2,059,503	33.5 kb	Distal (>10kb) Multiome	366
chr17:2,302,778–2,304,288	278.4 kb	Distal (>10kb) Multiome	770

Genome Browser

Genomic view of the RTN4RL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.