Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RTF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:56,358,373–56,359,678 | 109.8 kb | Distal (>10kb) Multiome | 612 | |
| chr20:56,391,539–56,393,046 | 76.2 kb | Distal (>10kb) Multiome | 1080 | |
| chr20:56,468,222–56,468,931 | 101 bp | At TSS Multiome | 887 | |
| chr20:56,624,898–56,625,604 | 156.4 kb | Distal (>10kb) Multiome | 210 | |
| chr20:56,628,380–56,631,136 | 161.7 kb | Distal (>10kb) Multiome | 551 | |
| chr20:56,690,044–56,691,001 | 221.9 kb | Distal (>10kb) Multiome | 191 | |
| chr20:56,736,238–56,736,823 | 267.8 kb | Distal (>10kb) Multiome | 206 | |
| chr20:56,748,308–56,749,036 | 280.0 kb | Distal (>10kb) Multiome | 90 | |
| chr20:56,750,435–56,750,924 | 282.0 kb | Distal (>10kb) Multiome | 88 |
Genomic view of the RTF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.